Association of liver biomarkers in T2DM patients, Northern Ethiopia: A cross-sectional study

Authors

  • Wegen Beyene Tesfamariam Mekelle University College of Health Sciences Author https://orcid.org/0000-0003-2814-3452
  • Rigat Alem Abrha Wollo Universitity Author
  • Dr. Desalegn Teklu Mekelle University College of Health Sciences Author
  • Gebrekidan Gebrezgabher Asfha Mekelle University College of Health Sciences Author
  • Dr. Hagos Amare Mekelle University College of Health Sciences Author
  • Dr. Abrha Gebreselama Mekelle University College of Health Sciences Author

DOI:

https://doi.org/10.83407/jn9s5b19

Keywords:

, Type 2 Diabetes Mellitus, liver function, Ethiopia

Abstract

Background

Liver disease, Non-Alcoholic Fatty Liver Disease (NAFLD) in particular, is a considerable cause of morbidity and mortality among patients with type 2 diabetes mellitus. Mounting evidence demonstrated that monitoring liver function biomarkers is critical for early detection and control of the disease. However, this relationship is not evaluated in the study setting.   

Objectives

To determine the association of liver biomarkers in T2DM Patients, Northern Ethiopia, from March 2020 to June2020.

Methods

Lifestyle and socio-demographic data were collected through interviews with the participants. Clinical data were reviewed from the medical record. Anthropometric measurements were taken following WHO protocol. Liver function markers were measured using an automated chemistry analyzer. The data was entered and analyzed using SPSS version 23. Categorical variables were presented using frequencies and percentages. Quantitative variables were described using means and standard deviations. Binary and multivariate logistic regressions were used to identify factors associated with liver function abnormalities.  

Results

A total of 331 (52.6% males) type 2 diabetes mellitus patients participated in this study. The mean fasting blood sugar level was 183±10.4mg/dl. Overall, 40% of the participants had abnormal liver function. In the multivariate analysis, male sex (AOR = 2.48; 95% CI: 1.43–4.31), duration of disease since diagnosis <5 years (AOR = 2.94; 95% CI: 1.30–6.63), alcohol intake (AOR =3.90, 95%CI:1.98-7.66), waist circumference (AOR = 3.81; 95% CI: 1.85-7.83), BMI ≥ 30kg/m2 (AOR = 3.96; 95% CI: 1.40–11.15), and FBS >200 mg/dl (AOR = 4.84; 95% CI: 1.33–17) were significantly associated with liver function abnormalities.  

Conclusions

Liver function abnormalities were common among T2DM patients at Ayder Comprehensive Specialized Hospital. Sex, disease duration, BMI, waist circumference, alcohol intake and fasting blood sugar were significant contributors for the observed liver biomarker derangement.

Author Biographies

  • Wegen Beyene Tesfamariam, Mekelle University College of Health Sciences

    Lecturer of Molecular Biology

    Department of Medical Biochemistry and Molecular Biology

  • Rigat Alem Abrha, Wollo Universitity

    Lecturer of Clinical Biochemistry

    Department of Pre-clerkship, School of Medicine

  • Dr. Desalegn Teklu, Mekelle University College of Health Sciences

    Assistant professor of Medical Biochemistry

    Department of Medical Biochemistry and Molecular Biology

  • Gebrekidan Gebrezgabher Asfha, Mekelle University College of Health Sciences

    Assistant professor of Medical Biochemistry

    Department of Medical Biochemistry and Molecular Biology

  • Dr. Hagos Amare, Mekelle University College of Health Sciences

    Assistant professor of Human Nutrition

    Department of Medical Biochemistry and Molecular Biology

  • Dr. Abrha Gebreselama, Mekelle University College of Health Sciences

    Assistant professor of Medical Biochemistry

    Department of Medical Biochemistry and Molecular Biology

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Published

06-06-2024

How to Cite

1.
Association of liver biomarkers in T2DM patients, Northern Ethiopia: A cross-sectional study. East Afr J Health Sci. [Internet]. 2024 Jun. 6 [cited 2025 Feb. 6];6(2):889-98. Available from: https://journal.mu.edu.et/index.php/eajhs/article/view/552